Fly brain dopaminergic neurons8/18/2023 ![]() Analysis of TH > mCD8::GFP and cell type-specific MARCM clones revealed that DA neurons show cluster-specific, stereotypical projection patterns with terminal arborization in target regions that represent distinct functional areas of the adult brain. DA neurons in the adult brain can be grouped into bilateral symmetric clusters, each comprising a stereotypical number of cells. Here we analyzed the DA system and motor behavior in aging Drosophila. However, an age-related analysis of these baseline parameters in wildtype Drosophila is lacking. Department of Neuroscience, Institute of Psychiatry, Medical Research Council Centre for Neurodegeneration Research, King’s College London, London, UKĭrosophila models of Parkinson’s disease are characterized by two principal phenotypes: the specific loss of dopaminergic (DA) neurons in the aging brain and defects in motor behavior.
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